Coagulation is a complex process by which blood forms clots. It is an important part of hemostasis (the cessation of blood loss from a damaged vessel), wherein a damaged blood vessel wall is covered by a platelet and fibrin-containing clot to stop bleeding and begin repair of the damaged vessel. Disorders of coagulation can lead to an increased risk of bleeding (hemorrhage) or clotting (thrombosis).
Coagulation begins almost instantly after an injury to the blood vessel has damaged the endothelium (lining of the vessel). Platelets immediately form a plug at the site of injury; this is called primary hemostasis. Secondary hemostasis occurs simultaneously: Proteins in the blood plasma, called coagulation factors or clotting factors, respond in a complex cascade to form fibrin strands, which strengthen the platelet plug.
Sonoclot Coagulation and Platelet Function Analyzer: Sonoclot is a versatile, whole blood point of care system that uses a viscoelastic clot detection mechanism to analyze the global process of hemostasis, including coagulation, fibrin gel formation, clot retraction (platelet function) and fibrinolysis. The Sonoclot uses the oscillation of a tubular probe within a blood sample to generate an electronic signal that reflects resistance to motion during clot formation and fibrinolysis. The Sonoclot Coagulation & Platelet Function Analyzer is an instrument for monitoring global hemostasis performance. This instrument can provide information on multiple components of hemostasis with a single test. Conventional coagulation analyzers can time the clot formation process but do not have the capabilities to provide additional information on fibrin formation, Platelet Function (clot retraction), or hyperfibrinolysis / DIC. The primary clinical use of Sonoclot Analyzer is to improve patient management during bleeding. The Sonoclot Analyzer is typically used in demanding clinical applications such as cardiovascular surgery, liver transplantation, obstetric bleeding complications, or other severe bleeding situation. Data processing by a microcomputer generates a qualitative graph (Sonoclot Signature) as well as quantitative results on clot formation kinetics and the rate of fibrin polymerization. A variety of different reagent kits are available for general coagulation monitoring, as well as more specific purposes, including heparin monitoring, hyperfibrinolysis screening, hypercoagulable screening and platelet function assessment.Coagulation, Thromboelastography Analyzer TEG Machine Anesthesia Liver Transplant Cardiac Surgery India